When it comes to all aquariums, the larger the system the larger its ability to manage issues. The solution is dilution in this hobby. You can simply get away with not doing water changes for a longer period of time...what my belief of what 'old tank syndrome' really is. Because even when you are dosing, what is removing the bad?
I personally have a protein skimmer, nitrate media, and an algae turf scrubber on my tank. I haven't done a water change in a year because of it. Just because I did it does not make it right! It has been an entire year battling other issues like aiptasia. Once things were under control...a large water change and things all come back to life. It doesn't do that for no reason...